Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease
K Jiménez-Aligaga, P Bermejo-Bescós… - Bioorganic & medicinal …, 2013 - Elsevier
… In summary, we have discovered that 2-arylvinylboronic acids and some of their esters …
them highly useful as neuroprotective agents affecting multiple biological targets involved in AD. …
them highly useful as neuroprotective agents affecting multiple biological targets involved in AD. …
The Cracked Potential of Boron-containing Compounds in Alzheimer's Disease
MA Soriano-Ursúa… - … Nervous System Agents …, 2023 - ingentaconnect.com
… as potential drugs considering multiple targets, suggested by … Hence, some BCC (precisely
some alkenylboronic acids) … -inflammatory and neuroprotective agent with multiple protective …
some alkenylboronic acids) … -inflammatory and neuroprotective agent with multiple protective …
COEXPEDIA: exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH)
… When we submitted a group of 16 genes associated with Alzheimer's disease (… alkenylboronic
acids have a neuroprotective function and can affect multiple biological targets involved …
acids have a neuroprotective function and can affect multiple biological targets involved …
[HTML][HTML] The role of microbiome in brain development and neurodegenerative diseases
V Nandwana, NK Nandwana, Y Das, M Saito, T Panda… - Molecules, 2022 - mdpi.com
… This review’s main goal is to summarize what is currently … further lead to the discovery of
two other drugs ixazomib and … novel neuroprotective agent and drug delivery method in the …
two other drugs ixazomib and … novel neuroprotective agent and drug delivery method in the …
Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases
M Barrón-González, AV Montes-Aparicio… - Journal of Inorganic …, 2023 - Elsevier
… reactions can be observed in many biological targets [5]. The … diminished inflammation in
Alzheimer's disease (AD) in in- … used in PD treatment as a novel neuroprotective agent and drug…
Alzheimer's disease (AD) in in- … used in PD treatment as a novel neuroprotective agent and drug…
[HTML][HTML] Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat
M Barrón-González, MC Rosales-Hernández… - International Journal of …, 2022 - mdpi.com
… of the boron moiety to the amino acid segment of L-tryptophan, … involved in the cognitive
deficit are unclear, but several … and borolatonin exert neuroprotection in hippocampal areas. In …
deficit are unclear, but several … and borolatonin exert neuroprotection in hippocampal areas. In …
[HTML][HTML] Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders
… activity on multiple targets, those that demonstrate a pro-survival … The challenge in
pharmaceutical research is discovering devices … In conclusion, SA NPs play a neuroprotective role …
pharmaceutical research is discovering devices … In conclusion, SA NPs play a neuroprotective role …
Exploring the Multitarget Activity of Wedelolactone against Alzheimer's Disease: Insights from In Silico Study
… (19,20) Thus, drug developers are becoming interested in finding both AChE and BChE …
affinity for two target receptors. It interacts favorably with essential amino acid residues in these …
affinity for two target receptors. It interacts favorably with essential amino acid residues in these …
Boronic acid group: A cumbersome false negative case in the process of drug design
S Katsamakas, AG Papadopoulos… - Molecules, 2016 - mdpi.com
… found to present various biological activities: Neuroprotection [7]… Thus, several researchers
have tested various boronic acid … The enzyme autotaxin (ATX) was used as a biological target …
have tested various boronic acid … The enzyme autotaxin (ATX) was used as a biological target …
… , is of high interest since many studies have proven its bioactivity. During the past few years, Δαβ-butenolides have been important synthetic targets, with several …
AF Villamizar-Mogotocoro… - Mini-Reviews in …, 2020 - ingentaconnect.com
… , anti-carcinogenic and neuroprotective activities. They also … , 2-benzothiopheneboronic
acid and alkenylboronic acid) [26… is mainly responsible for Alzheimer's disease [119]. …
acid and alkenylboronic acid) [26… is mainly responsible for Alzheimer's disease [119]. …